Federal investigators from the National Transportation Safety Board (NTSB) have launched an inquiry into the crash of an Amazon Air cargo plane at Miami International Airport, which killed five people and injured five others.

The NTSB confirmed it will hold a news conference on Monday to deliver initial findings. While I previously reported that the Federal Aviation Administration would lead the investigation, federal aviation crashes in the United States are formally investigated by the NTSB.

More than 200 firefighters responded to the scene, according to Miami Fire Chief Raied Jadallah. Emergency crews brought the heavy blaze under control, though officials warned that an active fuel leak remains at the crash site.

Chief Jadallah said several victims were trapped inside or underneath vehicles and had to be extricated by rescue teams. The aircraft came to rest near a car park servicing an Amazon warehouse and other businesses at the north-west perimeter of the airfield.

Miami-Dade County Mayor Daniella Levine Cava confirmed the five deaths at a news conference, adding that five injured individuals were taken to hospital, three of whom remain in a critical condition.

The Boeing 767-300, operated by North Carolina-based charter carrier 21 Air as Flight 7598 from San Juan, Puerto Rico, overran a diagonal runway just before 2:00pm local time (19:00 GMT). The crash prompted the FAA to halt all flights at the airport during the busy Labor Day weekend.

Amazon issued an updated statement expressing condolences: "Our deepest sympathies go out to the families, loved ones, and all those affected by this devastating loss. The airplane, which was operated by 21 Air, was attempting to land when this incident occurred. We're working closely with local authorities and officials to learn more and will cooperate fully with any investigation."

The exact cause of the runway overrun remains undetermined. I will continue to provide updates as the NTSB begins its formal investigation.